San Francisco visits Seattle at 4:25 p.m. Eastern on FOX. The 49ers are 4–0; the Seahawks are 3–1 and 2–0 at home.
Reported facts and availability
San Francisco’s current injury list rules out edge rusher Nick Bosa, fullback Kyle Juszczyk, safety Marques Sigle and defensive lineman James Thompson Jr. Corner Upton Stout is questionable. Brock Purdy has led the unbeaten start, while Christian McCaffrey remains central to the offense.
Seattle lists running back Zach Charbonnet and linebacker Chazz Surratt out; George Holani is questionable. The Seahawks’ official game center also notes the signing of cornerback Trevon Diggs from the practice squad. Sam Darnold leads an offense facing a short-handed San Francisco front.
ISR analysis: where the game can turn
Without Bosa, San Francisco has to decide how much pressure it can manufacture without weakening coverage. Seattle can help Darnold by forcing the defense to honor the run and by moving the launch point, but empty formations may still reveal the 49ers’ pressure intentions.
Seattle’s defense must treat McCaffrey as both a runner and a coverage problem. The useful measure is not only his rushing total; it is how often his alignment forces a linebacker or safety into conflict before the snap.
Both clubs have won through efficient stretches, but division games can magnify hidden yards. Punt placement, return decisions and penalties can determine whether either offense has to sustain an 80-yard drive.
Factors to watch
- San Francisco’s four-man pressure without Bosa.
- McCaffrey’s alignment and Seattle’s coverage response.
- Darnold’s time to throw on third down.
- Seattle’s running-back rotation without Charbonnet.
Market snapshot and source check
Source: Draft Kings odds displayed by ESPN’s game page, checked October 11, 2026, 7:25 a.m. EDT. Displayed line: SEA -3; total 45.5. This is a timestamped source snapshot, not a closing-line claim or a betting recommendation. Scheduled starters and availability may change before the game.
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