San Francisco visits Atlanta on Sunday at 1 p.m. Eastern on FOX. The 49ers are 6–0; the Falcons are 2–4.
Reported facts: both teams are reshuffling important roles
San Francisco ruled out receivers Mike Evans and Deebo Samuel Sr., defensive lineman Nick Bosa, linebackers Luke Gifford and Garret Wallow, and safety Marques Sigle. Christian Kirk, Siran Neal and Upton Stout were questionable.
Atlanta ruled out running back Brian Robinson Jr., linebacker Divine Deablo, defensive back Billy Bowman Jr. and tackle Michael Jerrell. Ten Falcons were listed questionable, including A.J. Terrell Jr. and C.J. Henderson.
ISR analysis: depth affects more than the substitute
San Francisco’s receiving absences shift route and target responsibilities. The useful question is whether Brock Purdy retains the same sequence of answers against pressure, not simply whether one replacement catches a pass.
Atlanta’s defensive communication changes without Deablo, while uncertainty in the secondary affects how aggressively the Falcons can challenge routes. San Francisco’s missing pass rushers create a separate protection test for Atlanta.
Factors to watch
- San Francisco’s route distribution without Evans and Samuel.
- Atlanta’s communication without Deablo.
- Which questionable cornerbacks are active.
- Pressure created without Bosa and the coverage cost required.
Market snapshot and source check
Source: DraftKings odds displayed by ESPN’s game page, checked October 25, 2026, 7:25 a.m. EDT. Displayed line: SF -2.5; total 50.5. This is a timestamped source snapshot, not a closing-line claim or a betting recommendation. Availability may change before kickoff.
