Washington visits San Francisco at Levi's Stadium on Monday at 8:15 p.m. Eastern on ESPN and ABC. The 49ers are 5–0; the Commanders are 1–3–1 after a 27–27 overtime tie with the Giants.
Reported facts: quarterbacks, recent form and availability
Brock Purdy is San Francisco's expected quarterback; Jayden Daniels leads Washington. Purdy has 1,196 passing yards, 13 touchdowns and two interceptions this season. The 49ers won their latest game 32–29 at Seattle. Daniels was a full participant throughout Washington's final practice week after his elbow issue, with no final game designation.
San Francisco ruled Deebo Samuel Sr., Nick Bosa, Garret Wallow and Marques Sigle out. Mike Evans and Christian Kirk are among six questionable players; Kirk's participation also depends on activation. Kyle Juszczyk is expected to return after missing the Seattle game. A returning fullback and an unsettled receiving group affect different parts of the offense.
Washington ruled leading rusher Jacory Croskey-Merritt out with a groin injury, along with Marcus Mariota, Charles Omenihu and Javontae Jean-Baptiste. Rachaad White and Austin Ekeler are available backfield alternatives. Stefon Diggs, Javon Kinlaw and Nick Cross were among the questionable players on the final report.
The clubs' pregame inactive lists can still resolve these conditional assignments. Traveling with the team or completing a limited practice does not guarantee participation.
ISR analysis: watch who carries each responsibility
Without Croskey-Merritt, Washington's rushing and protection duties have to be distributed differently. A change at running back can affect an outlet route or a pressure pickup even when the opening formation looks familiar. Watch how those jobs support Daniels before judging the offense only by its first few carries.
San Francisco's defensive absences make its pressure arrangement important. If an extra defender is needed to hurry Daniels, identify the coverage responsibility that player leaves behind. If the front creates pressure without that help, Washington faces a different passing picture.
At the other end, Juszczyk's anticipated return can change the run presentation and blocking choices. It does not resolve the separate question of which receivers Purdy will have. Evans' final status and Kirk's eligibility remain meaningful checkpoints.
Factors to watch
- Final status and activation decisions for the questionable receivers.
- Washington's division of backfield carries, protection and receiving work.
- San Francisco's pressure choices without Bosa.
- How Juszczyk's role changes the defensive response to the first action.
Market snapshot and source check
Source: DraftKings odds displayed by ESPN’s game page, checked October 19, 2026, 7:53 a.m. EDT. Displayed line: SF -7.5; total 51.5. This is a timestamped source snapshot, not a closing-line claim or a betting recommendation. Scheduled starters and availability may change before the game.
